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PubMed · 3481697

Human gene mapping.

R Williamson
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Abstract

It is now possible to map the human genome completely with a set of closely linked markers. Over 500 coding genes have been cloned and localized, as have approximately 2000 anonymous DNA fragments, most of which recognize two-allele polymorphisms that are caused by single base changes which alter the recognition site for a restriction enzyme (restriction fragment length polymorphisms). Most human chromosomes have been mapped, with markers in defined order placed approximately 10 map units apart. Chromosomes X and 21 are particularly well mapped, with over 200 probes ordered on X. The strategy during the next few years will encompass moving from a linkage map to a set of overlapping cosmid or phage clones, and finally to a complete sequence of regions of chromosomes and entire chromosomes. A complete sequence of the human genome should transform our understanding of development, the control of gene expression, and the parameters of genetic disease.

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Chromosome MappingCleft PalateCoronary DiseaseGenetic LinkageGenetic MarkersGenetics, MedicalHumansJournal ArticleResearch Support, Non-U.S. Gov't

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R Williamson. 1987. Human gene mapping.. https://doi.org/10.1002/9780470513507.ch2

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