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PubMed · 3426591

Decrease in total and free magnesium concentration following traumatic brain injury in rats.

R Vink·T K McIntosh·P Demediuk·A I Faden
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Abstract

31P magnetic resonance spectroscopy was used to determine the intracellular free Mg2+ concentration prior to and following fluid percussion induced traumatic brain injury in rats. Prior to injury, cerebral intracellular free Mg2+ concentration in the rat was 0.93 +/- 0.19 mM (mean +/- SE; n = 5). Following injury, free Mg2+ in the injured cortex declined by 70% within the first hour, and did not recover over the next 3 hours. Total Mg2+ also declined by 10% over this time period; however, there were no changes in brain Na+ or tissue water content. Because of its primary role in cellular metabolism, the early decline in tissue Mg2+ following brain trauma may be a critical factor in the development of irreversible tissue injury.

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Adenosine TriphosphateAnimalsBrain EdemaBrain InjuriesHydrogen-Ion ConcentrationMagnesiumMaleRatsRats, Inbred StrainsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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R Vink, T K McIntosh, P Demediuk, A I Faden. 1987-12-16. Decrease in total and free magnesium concentration following traumatic brain injury in rats.. https://doi.org/10.1016/0006-291x(87)90409-8

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