PubMed · 3344235
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P Gough, P Hingley. Combating the pressure.. https://pubmed.ncbi.nlm.nih.gov/3344235/
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The bed nucleus of the stria terminalis (BNST) was lesioned in adult male Wistar rats (n = 9) and its involvement in coping behavior during forced swim stress examined. Rats remain immobile longer in the second of two swim tests, a phenomenon known as learned despair. Results revealed that, compared to sham-operated controls (n = 8), BNST-lesioned animals displayed immobility significantly earlier and for longer durations in the second swim test. Rats with BNST lesions also showed significantly reduced escape behavior in the form of fewer numbers of jumps and dives compared to controls. Mobility deficits were not due to general motor impairment as revealed by an open field test. Results suggest that the BNST may modulate coping behavior especially during uncontrollable stress.
This study investigated four correlates of diabetes as potential predictors of sleep disruption in people with Type II diabetes. A tentative causal model proposed obesity would lead to more severe diabetes, which would result in increased physical complications, which might in turn affect emotional adjustment, and all of these might combine to cause sleep disruption. It was found that within a diabetic sample, severity of diabetes was related to sleep disruption. Path analysis indicated that the relationship between Type II diabetes and sleep disruption was mediated by physical complications of the disease (pain and nocturia), and not by either obesity or emotional adjustment.