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PubMed · 3277421

Renal function in hypertension.

A Mimran
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Abstract

Hypertension certainly accelerates the age-related changes in renal structure and function, mainly in the glomerulus. Both sodium handling and the renin-angiotensin system are involved in the aging process. Among the available classes of antihypertensive agents, the eventual deterioration of renal function induced by angiotensin-converting enzyme inhibitors in bilateral stenosis and stenosis of a single functioning kidney suggests that changes in glomerular pressure may participate in the changes of renal function. In essential hypertension and other conditions, it is possible that at a certain stage an increase in intraglomerular capillary pressure plays a role in the acceleration of the loss in renal function. As a consequence, it is proposed that in treating hypertension we should aim at reducing systemic blood pressure together with an attempt to reduce intraglomerular pressure using agents that act predominantly on post-glomerular resistance in order to have renal protection.

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Acute Kidney InjuryAngiotensin-Converting Enzyme InhibitorsHemodynamicsHumansHypertensionKidneyKidney TransplantationRenal Artery ObstructionRenin-Angiotensin SystemSodiumJournal ArticleReview

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A Mimran. 1988-01-29. Renal function in hypertension.. https://pubmed.ncbi.nlm.nih.gov/3277421/

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