PubMed · 3247968
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A Schinzel. 1988. [Computer search program for chromosome aberrations].. https://pubmed.ncbi.nlm.nih.gov/3247968/
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The frequency of chromosomal aberrations was evaluated in more than 500 liquidators of the Chernobyl accident. The 'sarcophagus' builders and the dosimetrists showed the highest frequency of aberrations per 100 cells: 3.24 +/- 0.25 and 3.11 +/- 0.43. For Chernobyl Atomic Power Station staff members the mean frequencies of aberrations per 100 cells was 2.37 +/- 0.20. The mean yields of aberrations in the other groups was between 1.31 and 1.47 per 100 cells. If the mean frequencies of aberrations are converted into equivalent whole body doses, values between 136 and 414 mGy are obtained. Especially in the group of 'sarcophagus' builders, the yields of aberrations varied interindividually and corresponded to equivalent whole body doses of up to about 2 Gy.
Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12ql3-15, and atypical lipomatous tumors (ALT) by supernumerary ring chromosomes or giant markers known to contain amplified 12q sequences. In a series of 228 cytogenetically analyzed and histopathologically reexamined ordinary lipomas and ALT, 10 tumors showed unbalanced chromosome-12 aberrations. All 4 tumors with loss of segments from 12q were classified as ordinary lipomas, whereas 5 of the 6 tumors showing gain of 12q material were diagnosed as ALT. One or three extra copies of 12q15-q24 were present in all 5 ALT. We conclude that duplication of 12q sequences may be a sufficient level of amplification for development of the microscopic appearance that characterizes ALT.
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