New regression function for absorption kinetics.

Abstract

A new formula for regression analysis is given to describe the concentration values gained experimentally following extravascular administration (oral and intramuscular). Since it is a correction to the equations for the open one- or two-compartment model, the advantages of clinical interpretation are retained, and it is easy to gain starting values. The new equation not only ensures much better emulation near the curve maximum, but is also applicable for curves with a broadened maximum or with two peaks.