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PubMed · 3068793

Amyloidosis.

C P Maury
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Abstract

Recent studies have provided new insight into the pathogenesis of amyloidosis and have broadened our knowledge of the mechanisms of deposition and resolution of amyloid. In particular, the structure, synthesis and plasma clearance of the inflammation-associated amyloid precursor, SAA, have been extensively studied and the precursor-product relationship between circulating SAA, protein AA and fibrillar amyloid A clarified. Information has been accumulating about the enzymatic processes involved in the cleavage of SAA and the degradation of protein AA and a new view has been presented on the possible role of amyloid P component in AA amyloidogenesis. The current model of AA pathogenesis emphasizes the dynamic character of amyloid.

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AmyloidosisGenetic MarkersHLA-DR AntigensHumansModels, BiologicalPolymorphism, GeneticRheumatoid FactorSerum Amyloid A ProteinSerum Amyloid P-ComponentJournal ArticleResearch Support, Non-U.S. Gov'tReview

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C P Maury. 1988. Amyloidosis.. https://doi.org/10.3109/03009748809102937

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PubMed2007

Schistosoma-induced amyloidosis in hamsters is gender-dependent.

BACKGROUND: A high serum level of female protein (FP), found to be a constituent of Syrian hamster amyloid was associated with enhanced amyloidosis. In this work, we studied the sex-limited factors in the induction of amyloidosis in Syrian hamsters infected with either Schistosoma mansoni or S. hematobium cercariae. METHODS: Hamsters were infected with different species of schistosome cercariae and sacrificed after different time periods of infection. Kidney and liver specimens were processed in paraffin, stained with Congo-red and examined by ordinary light and polarized light microscopy. RESULTS: Statistical analysis showed a significant difference in intensity of kidney and liver amyloid deposits (P<0.002 & <0.007 respectively) between females and male hamsters with extensive deposits in the former. Amyloid deposits were correlated significantly to the duration of infection (P<0.001) than the load of worm recovered. CONCLUSION: From this study, we conclude that, in hamster model, Schistosoma-induced amyloidosis is enhanced in females than male hamsters. This may be due to the high serum level of FP that is normally detected in females. As an experimental model for schistosomal nephropathy, we recommend to use male hamsters instead of females to minimize the effect of amyloid deposits, which may mask other pathological changes associated with schistosomal infection.

Amyloidosis↗