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PubMed · 3010085

[EBV diseases].

J Weber
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Abstract

Epstein-Barr virus (EBV) infection in early childhood is usually asymptomatic or associated with symptoms common to many other viral infections, such as pharyngitis, bronchitis or enteritis. Typical infectious mononucleosis, as seen in young adult patients, is rare in early childhood. There is also a lower rate of heterophil antibody responses in young children. Many complications of the infection are known, and many atypical manifestations can be identified as EBV-associated using modern EBV-specific serological methods. The problems of EBV infection during gestation and the neonatal period are described and the chronic and persistent infections, as well as the lymphoproliferative syndromes associated with EBV infection, are particularly taken into consideration.

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Antibodies, ViralAntigens, ViralB-LymphocytesBurkitt LymphomaChildChronic DiseaseDiagnosis, DifferentialEpstein-Barr Virus Nuclear AntigensFemaleHerpesviridae InfectionsHerpesvirus 4, HumanHumansImmunoglobulin GImmunoglobulin MInfant, NewbornInfectious MononucleosisNasopharyngeal NeoplasmsPregnancyPregnancy Complications, InfectiousT-LymphocytesViral Matrix ProteinsEnglish AbstractJournal Article

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J Weber. 1986. [EBV diseases].. https://pubmed.ncbi.nlm.nih.gov/3010085/

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Analysis and significance of anti-latent membrane protein-1 antibodies in the sera of patients with EBV-associated diseases.

Anti-latent membrane protein-1 (LMP-1) is an EBV-encoded type III integral membrane protein with oncogenic potential that is expressed most consistently in various EBV-associated malignancies. Unlike many other EBV proteins, LMP-1 Abs have rarely been demonstrated in EBV-associated disease conditions. We established a high level LMP-1-expressing cell clone and used it for the detection, quantitation, and characterization of these Abs in various human sera in immunoblots and ELISA. Our results demonstrate that, in contrast to the commonly held notion, LMP-1 induces significant humoral immune responses in EBV-associated malignant conditions especially in nasopharyngeal carcinoma (NPC) patients in whom >70% sera are positive for these Abs, and their titers correlate with the clinical condition of the tumors. Interestingly, anti-LMP-1 Abs of IgA isotype were found only in NPC patients. These Abs were absent from the sera of infectious mononucleosis and chronic EBV infection patients, whereas a small fraction ( approximately 5%) of the healthy, EBV-seropositive individuals were positive for them; however, their OD values were much lower than those of NPC patients. These studies demonstrate, for the first time, the potential significance of LMP-1-specific Abs for the diagnosis and prognosis of EBV-associated malignancies, especially of NPC.

Antibodies, Viral↗