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PubMed · 2996546

A catalyst function for MPTP in superoxide formation.

J Poirier·A Barbeau
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Abstract

We demonstrate that 1-methyl-4-phenyl-1,2-dihydropyridine (MPDP) can be generated, in an alternate pathway, from the catalyst action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) upon the iron redox equilibrium reaction. Superoxide and ferric iron are instantaneously produced after addition of MPTP to a solution of ferrous iron. This reaction is oxygen and pH dependent. Superoxide, through a iron dependent Haber-Weiss reaction with peroxide, can generate the cytotoxic hydroxyl radical. A small portion of the superoxide reacts with MPTP to produce the reactive species X. which, in the presence of Fe+3 can also generate MPDP.

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineCatalysisDeferoxamineFree RadicalsHydrogen-Ion ConcentrationIronKineticsOxidation-ReductionOxygenPyridinesSpectrophotometrySuperoxidesJournal ArticleResearch Support, Non-U.S. Gov't

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J Poirier, A Barbeau. 1985-09-30. A catalyst function for MPTP in superoxide formation.. https://doi.org/10.1016/0006-291x(85)90230-x

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