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PubMed · 2976166

Medroxyprogesterone acetate and tamoxifen do not decrease aggressive behavior in CF-1 male mice.

N G Simon·M Perry
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Abstract

Intact CF-1 male mice were given daily injections of either medroxyprogesterone acetate (MPA, an antiandrogen), tamoxifen (TAM, an antiestrogen), or the two drugs in combination and tested for aggressive behavior toward bulbectomized stimulus males. None of the treatments decreased fighting behavior over a 20-day test period and the presence of TAM led to increased aggression even in the presence of MPA. Testis weight was reduced by MPA while both compounds decreased seminal vesicle weight. The mechanisms involved in the observed effects are considered as well as the implications of the results for the clinical use of these compounds as modulators of testosterone-facilitated behaviors.

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AggressionAnimalsDelayed-Action PreparationsDrug InteractionsMaleMedroxyprogesteroneMedroxyprogesterone AcetateMiceMice, Inbred StrainsOlfactory BulbTamoxifenJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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N G Simon, M Perry. 1988. Medroxyprogesterone acetate and tamoxifen do not decrease aggressive behavior in CF-1 male mice.. https://doi.org/10.1016/0091-3057(88)90107-4

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From a functional perspective, deception can evolve in animal populations but should be constrained by the costs associated with detection. It then follows that withholding information should be more prevalent as a form of deception than active falsification of information because of the relative difficulties associated with detecting cheaters. Empirical studies of deception have focused on the benefits of cheating but have provided no data on the costs associated with being detected as a cheater. I present results from field experiments on rhesus monkeys (Macaca mulatta) which show that individuals discovering food announce their discoveries by calling on 45% of all trials. Discoverers who failed to call, but were detected with food by other group members, received significantly more aggression than vocal discoverers. Moreover, silent female discoverers ate significantly less food than vocal females. This demonstrates that there are significant costs to withholding information. Such costs may constrain the frequency with which deception occurs in this and other populations.

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