[Decrease of erythrocyte receptors for the C3b fragment of complement in acquired immunodeficiency syndrome].

J H Cohen; B Autran; M H Jouvin; J P Aubry; W Rozenbaum; J Banchereau; P Debré; J P Revillard; M Kazatchkine

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PubMed · 2968550

[Decrease of erythrocyte receptors for the C3b fragment of complement in acquired immunodeficiency syndrome].

J H Cohen·B Autran·M H Jouvin·J P Aubry·W Rozenbaum·J Banchereau·P Debré·J P Revillard·M Kazatchkine

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Abstract

The number of C3b receptors (CR1) on erythrocytes (E) was measured, using a newly developed flow cytometry assay and a standard radioimmunoassay, in HIV-infected individuals and in a normal control population. The number of CR1/E was significantly decreased in symptomatic HIV-infected patients with ARC and acquired immunodeficiency syndrome and was normal in asymptomatic carriers of anti-HIV antibodies. Decreased numbers of CR1/E correlated with the clinical severity of the HIV-related disease. A close correlation was found between results obtained with flow cytometry and those obtained with the radioimmuno-assay. Flow cytometric assessment of CR1/E may be of interest in large scale prospective clinical studies of HIV-infected subjects.

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J H Cohen, B Autran, M H Jouvin, J P Aubry, W Rozenbaum, J Banchereau, P Debré, J P Revillard, M Kazatchkine. 1988-04-23. [Decrease of erythrocyte receptors for the C3b fragment of complement in acquired immunodeficiency syndrome].. https://pubmed.ncbi.nlm.nih.gov/2968550/

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