PubMed · 2966758
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A Klajman, R Farkas, Y Manor, M Schneider. 1988-03-01. [B suppressor cells].. https://pubmed.ncbi.nlm.nih.gov/2966758/
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The immune response of an inactivated hepatitis A vaccine given to middle aged travellers 4-6 years after one single, primary dose was recently studied. All 25 vaccinees showed an impressive anamnestic booster response (GMT 2.993mIU/ml). The study confirms one previous report as well as experimental data, indicating a long-term proliferative T-cell response following one single primary dose of Havrix 1440. In 1999, Wiström et al. demonstrated that a booster 4 years after priming medical students with one single dose of a recombinant HB vaccine disclosed a rapid antibody response indicating a well-preserved memory. These reports put in focus the question: are we routinely offering too many doses of hepatitis A and B vaccines?
CD45 plays a critical regulatory role in receptor signaling through its protein tyrosine phosphatase and Janus kinase (JAK) phosphatase activities. To investigate whether CD45 also plays a regulatory role in Ig class switching in human B cells, we examined the effects of CD45 triggering on Ig class switching to IgE and its relationship with CD45 JAK phosphatase activity. Anti-CD45 triggering of CD45 significantly inhibited interleukin-4 + anti-CD40-induced switch recombination in a switch recombination vector assay in stably transfected Ramos 2G6 human B cells, as well as Ig epsilon germ-line transcription and Smu-Sepsilon switch recombination in primary human B cells. These negative regulatory effects on Ig class switching were concomitant with the ability of CD45 to dephosphorylate the induced phosphorylation of JAK1, JAK3, and signal transducer and activator of transcription 6, but not on stress-activated/mitogen-activated protein kinases. We also showed that phosphorylated JAK1 and JAK3 were directly dephosphorylated by recombinant CD45 in vitro. These results indicate that CD45 is able to function as JAK phosphatase in human B cells and that this activity is directly associated with the negative regulation of the class switch recombination to IgE. CD45 may be an appropriate target drug for modulating IgE in allergic diseases.
Majority of the Western population is infected with the Epstein-Barr virus. Except for mononucleosis accumulating in adolescents, the infection occurs in a rather symptomless manner. But later on under special circumstances the virus may play an important role, again. As a result of long-lasting and intensive immunosuppression i.e. following transplantation a lymphoproliferation of B cell origin may develop in some patients. The biologic behaviour is often more aggressive than expected by the histological occurrence. Early identification of predisposed patients is an important but difficult task: the disease exhibits a rather heterogeneous phenotype and the grading is problematic by the standard classification criteria of non-Hodgkin malignant lymphomas. Nevertheless the diagnosis and the therapy based on the appropriate pathomechanism can increase the chances of convalescence. This review article discusses the pathomechanism, diagnostic and therapeutic relevance of the posttransplant lymphoproliferative disease.