Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 2963285

[Delta hepatitis].

A Goudeau·F Dubois·P Leturcq
View original source ↗Export metadata ↓

Abstract

Hepatitis delta virus is a small defective RNA virus that replicates only in the presence of hepatitis B virus. Delta infections occur in two circumstances: co-infections where both viruses are acquired simultaneously, and superinfections where delta virus infects a patient who is already a chronic carrier of hepatitis B virus. In both cases, delta virus may induce a more severe outcome of the disease. Diagnostic tests of delta infection have recently become available and should be used in all cases of acute hepatitis B occurring in populations at risk of delta infection such as intravenous-drug addicts. Prevention of delta infection is essentially based on immunization against hepatitis B of populations exposed to both viruses.

Explore related subjects

Hepatitis AntibodiesHepatitis BHepatitis DHepatitis Delta VirusHumansVirus ReplicationEnglish AbstractJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

A Goudeau, F Dubois, P Leturcq. 1987-12-12. [Delta hepatitis].. https://pubmed.ncbi.nlm.nih.gov/2963285/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

Comparison of real-time reverse transcriptase-polymerase chain reaction and nested or commercial reverse transcriptase-polymerase chain reaction for the detection of hepatitis E virus particle in human serum.

Hepatitis E virus (HEV) was originally identified as the causative agent of enterically transmitted non-A, non-B hepatitis. The virus is the 7.5-kb single-stranded positive RNA virus and has been classified in the genus Herpevirus [corrected] of the [corrected] Herpeviridae [corrected] Recently, HEVs were identified from several countries worldwide from human and animals including swine. Studies on the genomic analysis of HEV isolates and seroprevalence of anti-HEV antibodies suggested that HEV has been considered as a potent zoonotic agent. The HEV infection has been diagnosed by detection of anti-HEV antibodies or virus by using reverse transcriptase-polymerase chain reaction (RT-PCR) methods in the blood or feces. However, these diagnostic methods were not quantitative and not enough to diagnose small amounts of target molecules. Moreover, these methods were not adequate during the incubation period or early acute phase. To overcome these problems, real-time RT-PCR method was developed with a cloned viral DNA and in vitro transcribed cRNA in this study. The sensitivity of the reaction was 1.68 x 10(1) copies per reaction. Correlation coefficient values of the reactions in the repeated experiments were over 0.99. Ranges of slopes and coefficient variation values were from 3.341 to 3.435 and from 1.20 to 5.98, respectively. In comparison of the real-time PCR with nested or commercial RT-PCR, HEV particles could be detected in the negative samples, which were determined by conventional nested RT-PCR.

Hepatitis Antibodies↗
PubMed2005

Hepatitis E infections, Victoria, Australia.

In the first half of 2004, acute hepatitis E virus infections diagnosed in Victoria, Australia, increased 7-fold. Of the interviewed patients with highly reactive serologic results, 90% reported recent clinically compatible illness and overseas travel. The increase is compared with a background of exposure in countries in which hepatitis E is endemic.

Hepatitis Antibodies↗