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PubMed · 2953677

Human T cell subsets.

P C Beverley
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Abstract

Several monoclonal antibodies (mAbs) demonstrate further heterogeneity of CD4 and CD8. Within CD4, two major subsets can be identified with helper/inducer and suppressor/inducer functions. It is argued that suppressor/inducers, identified by CD45R mAbs, are immature or virgin T cells and therefore respond poorly to recall antigens. Helper/inducers are CD45R negative but express the UCHL1 antigen, which appears to be part of CD45. These cells respond well to recall antigens and are therefore mature or memory T cells. Several antigens not related to CD45, such as 4B4, Leu8, TQ1 and 9.3, identify functionally distinct subsets rather than stages of T cell maturation.

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Antigens, Differentiation, T-LymphocyteAntigens, SurfaceHumansT-LymphocytesT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryJournal ArticleReview

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P C Beverley. 1987. Human T cell subsets.. https://doi.org/10.1016/0165-2478(87)90001-0

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