Human helper-T-cell function does not require T4 antigen expression.

S M Friedman; M K Crow; O H Irigoyen; C Russo; D N Posnett; L Rogozinski

doi:10.1016/0008-8749(86)90072-9

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PubMed · 2948666

Human helper-T-cell function does not require T4 antigen expression.

S M Friedman·M K Crow·O H Irigoyen·C Russo·D N Posnett·L Rogozinski

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Abstract

The relationship between immunoregulatory T-cell function and the expression of T-cell subset-specific differentiation antigens was examined using a phenotypically anomalous human T-cell line (TCL), termed H-1. H-1 cells were found to express T11, extremely high levels of T3, but no T4 nor T8 antigen. Despite their lack of T4 antigen expression, H-1 cells could be activated by coculture with pokeweed mitogen (PWM), anti-T3 antibody, or autologous B cells to provide potent help for B-cell differentiation into plaque-forming cells (PFC). In contrast, H-1 cells did not suppress the PFC response triggered by PWM-activated T4+ cells. These results demonstrate that the expression of the T-cell subclass-specific differentiation antigen, T4, is not required for a T cell to become activated and to implement the program for helper function. In addition, enhanced expression of T3 on the T4-, T8-, H-1 cell surface may reflect a compensatory upregulation of the T3/Ti receptor complex on T cells which are deficient in these nonpolymorphic associative recognition structures.

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Antigens, Differentiation, T-Lymphocyte Antigens, Surface B-Lymphocytes Cell Differentiation Cell Line Humans Lymphocyte Activation Lymphocyte Cooperation Phenotype Pokeweed Mitogens T-Lymphocytes, Helper-Inducer Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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S M Friedman, M K Crow, O H Irigoyen, C Russo, D N Posnett, L Rogozinski. 1986. Human helper-T-cell function does not require T4 antigen expression.. https://doi.org/10.1016/0008-8749(86)90072-9

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