PubMed · 2897142
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S M Otkjaer, N C Ahn. 1987-08-03. [Stimulants].. https://pubmed.ncbi.nlm.nih.gov/2897142/
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This paper describes a fast and simple method for the direct determination of the stimulant prolintane and its principal urinary metabolite, oxoprolintane, in human urine by capillary zone electrophoresis and beta-cyclodextrin-modified micellar electrokinetic chromatography. The determination was performed in phosphate buffer, pH 8.5, with UV detection at 211 nm. The effect of the ionic strength ratio between sample and running electrolyte, pH, sodium dodecyl sulphate and beta-cyclodextrin concentrations, and other factors, on the electrophoretic signals of these drugs was examined. This method can be applied for doping control. The determination limits are 1.0 microgram ml-1 for prolintane and 0.7 microgram ml-1 for oxoprolintane.
The current American medical practice paradox of concomitant overprescribing and underprescribing of controlled drugs is within the power of physicians to correct. It requires actively seeking education in traditionally neglected areas and avoiding prescribing controlled drugs to patients with either substance abuse histories or vague clinical indications. Attempts to limit prescribing to short therapeutic time courses, refusal to prescribe if pushed, and careful chart documentation practices are important. By increasing knowledge about chemical dependence and about chemically dependent patients' abnormal relationships with scheduled drugs, the current clinical reality can be reversed. This reversal will result in marked decreases in prescribing to the minority of patients (those with chemical dependence) and increases in prescribing to the majority of patients who are currently often undertreated.
A relatively rapid and simple means of enantiomer determination is described for the determination of methamphetamine, a common drug of abuse. The method employs the well known technique of infrared transmission spectrometry on solid samples dispersed within an alkali metal halide matrix. This approach exploits the solid-state, ion-exchange reaction between methamphetamine hydrochloride and a potassium iodide matrix and the subsequent formation of the hydriodide salt in situ. The infrared properties of the hydriodide salt are distinct for enantiomerically enriched and racemic samples, and therefore are readily distinguished by infrared transmission spectrometry. This technique uses materials and instrumentation that are generally available to most crime laboratories. The applicability of this method to some other amine drugs is discussed.