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PubMed · 2742580

Age-dependent decrease of carnitine content in muscle of mice and humans.

M Costell·J E O'Connor·S Grisolía
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Abstract

Carnitine deficiency associated with impairment of muscle function has been described in infants and young adults as a result of inherited or acquired disease but there are no reports on carnitine levels in healthy aging people. In this paper we show a marked reduction of carnitine and its derivatives in muscle, and of long-chain acyl carnitine in heart of 6-month-old mice, when compared to animals of 6 weeks of age. Analysis of muscle samples of healthy humans of different ages showed a drastic reduction of carnitine and acetyl carnitine in the older subjects with a strong reverse correlation between age and carnitine levels.

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AcetylcarnitineAcylationAdultAgedAgingAnimalsBrainCarnitineCarnitine O-AcetyltransferaseHeartHumansLiverMaleMiceMiddle AgedMuscle DevelopmentMusclesJournal ArticleResearch Support, Non-U.S. Gov't

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M Costell, J E O'Connor, S Grisolía. 1989-06-30. Age-dependent decrease of carnitine content in muscle of mice and humans.. https://doi.org/10.1016/0006-291x(89)91360-0

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