PubMed · 2700421
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M Elstein, E Eyong. 1989. The new progestogens.. https://doi.org/10.1007/bf01890896
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Over 30 years have elapsed since the introduction of the combination oral contraceptive pill. During this time, the estrogen and progestogen components of the pill have been reduced 80% and 90%, respectively. An improved understanding of the mechanisms involved in the metabolism of the oral contraceptive pill steroids now exists that allows us to better understand interactions of the pill with other drugs and medications. In an effort to reduce adverse reactions to the oral contraceptive pill, new progestogens have been developed for contraceptive pills soon to become commercially available. These issues as well as the concept of the pill-free interval are discussed in this review.
In addition to preventing pregnancy which in the wider sense of the word implies prevention of all complications of gestation, incl. extrauterine pregnancy, the use of steroid contraceptives has a favourable effect on some other diseases which are not directly associated with gestation. The authors give an account of all diseases where the use of steroid contraceptives may act as a preventive factor as regards the incidence of these disease and/or their intensity. This action is frequently omitted in the professional and lay press. The authors also draw attention to the advantages of modern steroid contraceptives with a minimal dose of oestrogens and on gestagens of the third generation.