PubMed · 2661977
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S R Graham, R O Day, M Hardy. 1989-07-17. Captopril overdose.. https://doi.org/10.5694/j.1326-5377.1989.tb101174.x
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An automated method to determine captopril (1-[(2S)-3-mercapto-2-methylpropionyl]-L-proline) is proposed. A flow injection manifold based on the indirect biamperometric detection of the captopril by using Fe(III)/Fe(II) as an indicating redox system and a Z-shaped flow-cell configuration, was developed. The calibration curve is linear over the range 0.03-3.6 microg ml(-1) of captopril. The relative standard deviation for the determination of 0.76 microg ml(-1) of captopril is 0.97% (n = 12) and the sample throughput is 69 h(-1). This method was applied to the determination of captopril to commercially available pharmaceutical preparations.