PubMed · 2455939
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Z S Han. 1988. [Nonsynaptic transmission].. https://pubmed.ncbi.nlm.nih.gov/2455939/
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Psilocybin poisoning produces biphasic reactions composed of a schizophrenic phase and a panic attack-like phase. There is a time lag of several hours between phases, which may be considered an accumulation time in certain sites between the gut and the brain. So far as 5-hydroxytryptamine (5-HT) congeners are concerned, no sites are to be found except the amine precursor uptake and decarboxylation (APUD) system. It is postulated that argyrophil cells (AC) in the foregut, neuroepithelial bodies (NEB) in the lung, and raphe nuclei (RN) in the brainstem axis are relevant to mental disorders. Schizophrenia might be due to the massive destruction of APUD cells, and the paroxysmal release of 5-HT with peptides and panneuroendocrine markers from NEB might be the cause of panic attack.
In 6 patients with uncomplicated gastric ulcer (GU) and 8 patients with GU complicated by acute bleeding morphohistochemical and ultrastructural analysis of apudocytes of gastric mucous membrane in the ulcer, periulcer and remote zone was carried out with detection of morphofunctional changes predicting ulcer bleeding. It is established that G- and ECL-apudocytes hyperplasia and hyperfunction in these zones have stable, irreversible nature in gastric ulcer bleeding, and are reliable prognostic criteria of this complication.
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