Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 2406210

Fluorides.

P Städtler
View original source ↗Export metadata ↓

Abstract

Remineralization of early lesions and inhibition of demineralization are considered to be the prevailing mechanisms of action of fluorides. For this purpose a number of preparations are available today. Before applying them, one should be aware of their concentration, correct prescription, dosage, pharmacokinetics and potential side and after-effects.

Explore related subjects

Administration, TopicalDental CariesFluoridesHumansWater SupplyJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

P Städtler. 1990. Fluorides.. https://pubmed.ncbi.nlm.nih.gov/2406210/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1992

Synthesis and physicochemical properties of sulfamate derivatives as topical antiglaucoma agents.

Several imidazolylphenyl sulfamate and (imidazolylphenoxy)alkyl sulfamate derivatives were synthesized and evaluated as topically active carbonic anhydrase inhibitors. Water solubility, pKa, carbonic anhydrase inhibition, and partition coefficient for the compounds were measured. Sulfamic acid 2-[4-(1H-imidazol-1-yl)phenoxy]ethyl ester monohydrochloride (16) has the best combination of properties and showed excellent topical activity in lowering the intraocular pressure in New Zealand white rabbits.

Administration, Topical↗
PubMed1992

Results of intraoperative 5-fluorouracil supplementation on trabeculectomy for open-angle glaucoma.

The success rate of filtration surgery has been increased by the postoperative subconjunctival injection of 5-fluorouracil, a potent antimetabolite. However, the optimal route of administration has not been determined. Trabeculectomy was performed on one eye each of 14 patients. Topical 5-fluorouracil was applied intraoperatively (50 mg/ml for five minutes) and subconjunctival 5-fluorouracil was injected postoperatively (an average of 5.8 injections) (mean total dose, 29 mg). Seven of the 14 eyes had primary open-angle glaucoma, and seven eyes had open-angle glaucoma with either uveitis, aphakia, or previous failed trabeculectomy. Mean preoperative intraocular pressure was 24.7 mm Hg during treatment with an average of three antiglaucoma medications, and mean final intraocular pressure was 11.9 mm Hg during treatment with an average of 0.2 medication. Thirteen of 14 eyes (93%) had final intraocular pressure of 18 mm Hg or less. Mean follow-up was 6.4 months (range, four to nine months). No remarkable complications occurred. Visual acuity remained stable in 13 of 14 eyes (93%). Intraoperative 5-fluorouracil may be a helpful adjunct in achieving low final intraocular pressure after trabeculectomy.

Administration, Topical↗
PubMed1992

[Pannus].

Explore the source record for details and available documents.

Administration, Topical↗