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Computer simulation (based on a linear-elution-strength approximation) as an aid for optimizing separations by programmed-temperature gas chromatography.

D E Bautz·J W Dolan·W D Raddatz·L R Snyder
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Abstract

If the dependence of retention on temperature is specified for the various components of a sample in isothermal gas chromatography (GC), it is possible to predict retention, bandwidth, and resolution for programmed-temperature GC separations as a function of experimental conditions. The use of a linear-elution-strength (LES) approximation for isothermal retention allows these predictions to be carried out more easily and conveniently, in turn facilitating rapid simulations with a personal computer. This approach to GC method development appears promising, especially if segmented-temperature programs are used. The LES approximation also provides added insight into how different factors affect separation in programmed-temperature GC.

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Chromatography, GasComputer SimulationTemperatureJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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D E Bautz, J W Dolan, W D Raddatz, L R Snyder. 1990-08-01. Computer simulation (based on a linear-elution-strength approximation) as an aid for optimizing separations by programmed-temperature gas chromatography.. https://doi.org/10.1021/ac00214a004

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