Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 22831

Thphenidate.

R Kadouch·R H Belmaker·R P Ebstein·L Peres
View original source ↗Export metadata ↓

Abstract

Plasma cyclic-AMP responses to adrenergic agonists are due to stimulation of the peripheral beta-adrenergic receptor. Mood responses to stimulants are thought to be due to actions leading to stimulation of central catecholamine receptors. To determine if a peripheral measure of receptor sensitivity could predict central mood effects of stimulants, the plasma cyclic-AMP response and the mood response to intravenous methylphenidate were determined simultaneously in 13 subjects. No correlation between the two responses was found.

Explore related subjects

Adjustment DisordersAdrenergic beta-AgonistsAdultBipolar DisorderBlood PressureCyclic AMPDepressionEmotionsFemaleHumansInfusions, ParenteralMaleMethylphenidateMiddle AgedJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

R Kadouch, R H Belmaker, R P Ebstein, L Peres. 1977. Thphenidate.. https://doi.org/10.1159/000117610

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1992

Platelet imipramine binding and plasma cortisol levels in Israeli civilians during the Gulf War.

[3H] Imipramine binding to platelets and plasma cortisol levels were measured in nine Israeli civilians before, during, and after repeated missile attacks. Hamilton Anxiety Rating Scale (HARS), and Beck Depression Inventory (BDI) were similar before and during the war and decreased significantly after the war. A trend toward increase in platelet imipramine binding values was observed during the war when compared with the postwar values (19%; p = 0.056), and/or when compared with prewar values (26%; p = 0.063). However, one-way analysis of variance with repeated measures did not reveal a significant statistical difference [F (2,6) = p = 2.07; NS] among the three time points. A significant correlation was found between HARS score, but not BDI, and imipramine binding values in the prewar and postwar time points (r = 0.87; 0.71, respectively). Plasma cortisol levels did not alter significantly during the study period.

Adjustment Disorders↗