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PubMed · 2207749

An algorithm for searching restriction maps.

W Miller·J Ostell·K E Rudd
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Abstract

This paper presents an algorithm that searches a DNA restriction enzyme map for regions that approximately match a shorter 'probe' map. Both the map and the probe consist of a sequence of address-enzyme pairs denoting restriction sites, and the algorithm penalizes a potential match for undetected or missing sites and for discrepancies in the distance between adjacent sites. The algorithm was designed specifically for comparing relatively short DNA sequences with a long restriction map, a problem that will become increasing common as large physical maps are generated. The algorithm has been used to extract information from a restriction map of the entire Escherichia coli genome.

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AlgorithmsRestriction MappingUser-Computer InterfaceJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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W Miller, J Ostell, K E Rudd. 1990. An algorithm for searching restriction maps.. https://doi.org/10.1093/bioinformatics%2F6.3.247

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