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PubMed · 2201499

Predicting type I diabetes.

A G Ziegler·R D Herskowitz·R A Jackson·J S Soeldner·G S Eisenbarth
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Abstract

Currently, there are three markers that are being studied with the potential to give a high positive predictive value for the development of type I diabetes (insulin-dependent diabetes caused by autoimmune beta-cell destruction) and that can be utilized to predict the disease in susceptible relatives: 1) high-titer cytoplasmic islet cell antibodies, 2) insulin autoantibodies detected with fluid-phase radiobinding assays, and 3) first-phase insulin release after intravenous glucose less than 1st percentile. With the combination of these assays, it seems to be possible to identify first-degree relatives with a high probability of developing type I diabetes within a limited time span (i.e., less than 10 yr). The ability to predict type I diabetes with selected assays will allow trials for prevention of diabetes and trials to assess whether prediction will decrease morbidity and mortality at onset of diabetes.

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AutoantibodiesBiomarkersChildDiabetes Mellitus, Type 1Disease SusceptibilityGenetic MarkersHumansInsulin AntibodiesIslets of LangerhansJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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A G Ziegler, R D Herskowitz, R A Jackson, J S Soeldner, G S Eisenbarth. 1990. Predicting type I diabetes.. https://doi.org/10.2337/diacare.13.7.762

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