Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 2199004

Oxygen toxicity.

R F Lodato
View original source ↗Export metadata ↓

Abstract

The paradox of oxygen therapy is that it can be both life saving and life destroying. Considered as one of the most important drugs available to the clinician, its "dose," determined as the product of the oxygen concentration used and the duration of its use, must be titrated to avoid toxicity while still achieving adequate systemic oxygenation.

Explore related subjects

Free RadicalsHumansOxygenOxygen ConsumptionRespirationJournal ArticleResearch Support, Non-U.S. Gov'tReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

R F Lodato. 1990. Oxygen toxicity.. https://pubmed.ncbi.nlm.nih.gov/2199004/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Kinetic study on the reaction of OH radical with dimethyl sulfide in the absence of oxygen.

A variational transition-state theory calculation for the reaction of OH radical with dimethyl sulfide (DMS) in the absence of oxygen is presented. The potential energy surface was previously studied and the effects of different levels of theory were analyzed. Here we propose a kinetic model for the atmospheric DMS oxidation in the absence of oxygen. For the first time, addition of OH to DMS and CH(3)SOH elimination channels are connected, and the equilibrium approximation in the high-pressure regime is applied to the DMS-OH adduct in the absence of oxygen. Both low- and high-pressure limits are considered to analyze the two different mechanisms of the H-abstraction channel, and two different kinetic approaches are applied to study them. The rate constants for the addition-elimination and H-abstraction routes are compared and the branching ratios are also studied. Tunneling contributions and kinetic isotope effects are analyzed. We conclude, in agreement with experimental observations, that in the absence of oxygen DMS oxidation takes place via H-abstraction with a branching ratio of 1.0 at atmospheric temperatures.

Free Radicals↗
PubMed2007

Synthesis and in situ atomic force microscopy characterization of temperature-responsive hydrogels based on poly(2-(dimethylamino)ethyl methacrylate) prepared by atom transfer radical polymerization.

Well-defined copolymers of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and benzophenone methacrylate (BPMA) with different compositions were synthesized via atom transfer radical polymerization. The molecular weights of these copolymers were Mn approximately 30 000 g/mol, while the BPMA content varied from 2.5 to 10 mol %. The copolymers with a low content of BPMA (2.5 and 5 mol %) exhibited a sharp thermal transition at 33-36 degrees C in aqueous solution. A hydrogel was immobilized and patterned on a silicon wafer via UV treatment of the spin-coated polymer layer using a photomask technique. The thermoresponsive behavior of the patterned polymer gel was quantitatively investigated by variable temperature in situ contact mode atomic force microscopy, which revealed the presence of two lower critical solution temperature regions. One region was between 25 and 30 degrees C, corresponding to the topmost layer of the hydrogel film, and the other region, around 40 degrees C, corresponded to the bulk of the hydrogel. Concurrent lateral force microscopy measurements revealed that, just above the transition temperature, the bulk region exhibited enhanced friction.

Free Radicals↗