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PubMed · 2130179

[Biologic risk].

L Lery·G Bontoux
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Abstract

In the biotechnology development, the biohazard become an important field of environmental medicine. After evaluation of biological agents, the laboratory organization in different security steps in achieved. One chapter "Health and Security" must be included in every scientific or industrial scheme of procedures. One example is given with the schedule for Hepatitis B and AIDS prevention.

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Acquired Immunodeficiency SyndromeContainment of BiohazardsHepatitis BHumansEnglish AbstractJournal Article

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L Lery, G Bontoux. 1990. [Biologic risk].. https://pubmed.ncbi.nlm.nih.gov/2130179/

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A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children.

Genetic modification of hematopoietic stem cells with genes that inhibit replication of human immunodeficiency virus-1 (HIV-1) could lead to development of T lymphocytes and monocytic cells resistant to HIV-1 infection after transplantation. We performed a clinical trial to evaluate the safety and feasibility of this procedure, using bone marrow from four HIV-1-infected pediatric subjects (ages 8 to 17 years). We obtained bone marrow, isolated CD34(+) cells, performed in vitro transduction with a retroviral vector carrying a rev-responsive element (RRE) decoy gene, and reinfused the cells into these subjects with no evidence of adverse effects. The levels of gene-containing leukocytes in peripheral blood samples in the 1 year after gene transfer/cell infusion have been extremely low. These observations support the potential of performing gene therapy for HIV-1 using hematopoietic cells, but emphasize the need for improved gene transfer techniques.

Acquired Immunodeficiency Syndrome↗