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PubMed · 199408

Persistent abnormalities in central nervous system function (long-term tolerance) after brief ethanol administration.

S E Gitlow·S W Dziedzic·L B Dziedzic
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3,4-Dihydroxyphenylacetic AcidAlcoholismAnimalsBrainCorpus StriatumDopamineElectroencephalographyElectromyographyEthanolFemaleHomovanillic AcidHumansHypothalamusMotor ActivityNorepinephrineRatsSleep, REMJournal Article

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S E Gitlow, S W Dziedzic, L B Dziedzic. Persistent abnormalities in central nervous system function (long-term tolerance) after brief ethanol administration.. https://doi.org/10.1016/0376-8716(77)90046-1

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A history of human-like dieting alters serotonergic control of feeding and neurochemical balance in a rat model of binge-eating.

OBJECTIVE: This study replicated a model of stress-induced binge-eating in rats with a history of caloric restriction (HCR), tested their response to SSRI (fluoxetine) treatment, and explored changes in brain monoamine levels. METHOD: Young female rats with no-HCR/no-Stress, no-HCR/Stress, HCR/no-Stress, and HCR+Stress (binge-eating) were treated with fluoxetine. Post-mortem levels of serotonin, dopamine, and metabolites were assessed from brain regions key to feeding and reward. RESULTS: A 3 mg/kg dose of fluoxetine without effect in the no-HCR groups suppressed intake of HCR groups, normalizing the binge-eating of HCR/Stress rats. No differences in monoamines were detected in the hypothalamus or tegmentum but a strong positive relationship between accumbens serotonin and dopamine turnover in no-HCR rats was absent in rats with HCR. CONCLUSION: Despite lack of hunger, a history of human-like dieting alters serotonin function in ways suggesting consequences not only to feeding but also control of reward and mood that are dependent on dopamine/serotonin interactions.

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