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PubMed · 1865558

Identifiability and parameter estimation.

J A Jacquez
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Abstract

In experiments on biological systems one often cannot measure all state variables (compartments). Given a particular experiment of that type, a basic kinetic parameter may have no effect on the observations; such a parameter is an insensible parameter for that experiment. A parameter may influence the observations and not be uniquely determinable; such a parameter is nonidentifiable for that experiment. Only identifiable parameters can be estimated uniquely, by that experiment. I review the basic theory to check identifiability for a nominal value of a parameter (local identifiability), and present some examples of problems that may arise in estimation.

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KineticsMathematicsMetabolismModels, BiologicalSoftwareJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J A Jacquez. Identifiability and parameter estimation.. https://doi.org/10.1177/014860719101500355s

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