PubMed · 1861663
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
R B Tompkins. 1991. MMA grapples with AIDS-testing policy.. https://pubmed.ncbi.nlm.nih.gov/1861663/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
Laboratory diagnosis of HIV infection is based on the detection of HIV antibodies. There is a delay between infection and seroconversion (i.e. the appearance of specific HIV antibodies) corresponding to a window period which may last several weeks. Reduction of the length of the window period might be achieved by using p24 antigen and/or viral nucleic acid detection assays. We have evaluated a new screening assay (VIDAS HIV DUO) designed for the concurrent detection of HIV antibodies and p24 antigen, using sequential samples of 34 HIV-1 seroconverting patients and 236 HIV-positive samples confirmed by Western blot. Results were compared with those obtained with two third-generation anti-HIV antibody screening assays. The 236 confirmed HIV-positive samples including 3 HIV-1 subtype O and 2 HIV-2 samples were found to be positive by the 3 assays. All 128 sequential samples from 34 seroconverting patients were found to be positive using the DUO assay, including 20/20 pre-seroconversion samples (p24 antigen-positive and anti-HIV negative). The new screening assay was positive before a third-generation anti-HIV screening assay gave positive results in 14/34 patients (41%). Using the DUO assay, the mean reduction of the window period was 4 days.
Explore the source record for details and available documents.