PubMed · 1859623
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S Sandhaus. 1991-03-31. [Cerasand ceramic implants].. https://pubmed.ncbi.nlm.nih.gov/1859623/
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The aim of this work is to understand the role of chemical and radiation induced crosslinking on the fatigue crack propagation resistance of medical grade ultrahigh molecular weight polyethylene (UHMWPE). In recent years, the need to improve the tribological performance of UHMWPE used in total joint replacements has resulted in the widespread utilization of crosslinking as a method to improve wear resistance. Although crosslinking has been shown to drastically improve the wear resistance of the polymer, the potential trade-off in fatigue properties has yet to be addressed. Fatigue crack propagation resistance is a concern in tibial inserts where large cyclic stresses are sufficient to drive the growth of subsurface cracks that potentially contribute to delamination wear mechanisms. For clinical relevance, the combined effects of sterilization and aging are examined in two commercially available crosslinked resins. Nonsterile and unaged resins serve as a control. To evaluate the effect of crosslinking, a comparison is made to uncrosslinked resins. Scanning electron microscopy is used to provide an understanding of fatigue fracture mechanisms in the crosslinked polymers. The results of this study show that the current level of crosslinking used in orthopedic resins for enhanced wear resistance is not beneficial for fatigue crack propagation resistance.
A new positively charged, submicronized fat emulsion with appropriate stability during the autoclaving process was developed. Only the emulsions prepared with a combination of ABA block co-polymer (F68) and chitosan were stable enough to resist the thermic shock induced by autoclaving sterilization. The results indicate that a mixed film consisting of the ABA block co-polymer and chitosan molecules was formed at the o/w interface with an overall positive surface charge. Conversely, a combination between chitosan with phospholipids and/or with a mixture of phospholipids with ABA block co-polymer showed a phase separation during autoclaving. A chitosan type with a low viscosity was used which was intended for a possible use in the ocular and parenteral application. An experimental factorial design 32 was used to investigate the effect of chitosan and F68 concentrations on the physicochemical properties of the system and consequently their influence on the stability of emulsions during autoclaving. Both size and surface charge of emulsions were significantly affected as a function of the chitosan concentration. Formulation with a mean particle size ranging from 125 to 130 nm and with a positive surface charge of 20-23 mV was achieved. Moreover, the chitosan emulsions were autoclaved without a significant change in their particle size. However, increasing the concentration of chitosan needs a higher amount of F68 in order to achieve stable emulsions during autoclaving. This may be due to the interaction between the positively-charged chitosan and the negatively-charged free fatty acids, which are contained in the oil phase (castor oil).
The development of a safe and efficient bioreactor design has remained a challenge for the clinical application of immobilized enzymes. Specifically, the use of immobilized heparinase I has been the target of many studies to make heparin anticoagulation therapy safer for the critically ill patient with kidney failure or heart disease. We have investigated the use of Taylor-Couette flow for a novel type of bioreactor. In a previous study, we showed that the fluidization of agarose immobilized heparinase within Taylor vortices in whole blood can lead to extensive blood damage in the form of cell depletion and hemolysis. Based on these findings, we designed and developed a reactor, referred to as vortex-flow plasmapheretic reactor (VFPR), that incorporated plasmapheresis and fluidization of the agarose in the reactive compartment, separate from the whole-blood path. In the present study, immobilized heparinase I was tested as a means of achieving regional heparinization of a closed circuit. This is a method in which heparin is infused into the extracorporeal circuit predialyzer and neutralized postdialyzer. Saline studies were performed with an immobilized heparinase I-packed bed and with the VFPR. An in vitro feasibility study was performed with the VFPR using human blood. The VFPR achieved heparin conversions of 44 +/- 0.5% and 34 +/- 2% in saline and blood, respectively. In addition, the VFPR caused no blood damage. We report a novel method to achieve fluidization which depended on secondary, circumferencial flow, and was independent of the primary flow through the device.