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PubMed · 1859608

Much blindness is avoidable.

B Thylefors
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Abstract

The main strategy of the World Health Organization's Programme for the Prevention of Blindness is to make simple eye care available to all populations. In many countries, national committees are responsible for the optimal utilization of resources and the coordination of work in this field. Several major international nongovernmental organizations provide support. Factors limiting the effectiveness of national programmes are being addressed in WHO collaborating centres.

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BlindnessDeveloping CountriesHumansWorld Health OrganizationJournal Article

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B Thylefors. 1991. Much blindness is avoidable.. https://pubmed.ncbi.nlm.nih.gov/1859608/

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Golgi-Kopsch silver study of the brain of a patient with untreated phenylketonuria, seizures, and cortical blindness.

This report describes the morphological changes observed in the brain of an untreated 27-year-old man with phenylketonuria, cortical blindness, and seizures. Golgi-Kopsch silver, cresyl violet, and hematoxylin and eosin stains were used to study cell structure and organization of the cerebellum, the lateral geniculate nuclei, the visual cortex, frontal cortex, and hippocampus. Extensive neuronal losses occurred in the right lateral geniculate nucleus (LGN), the visual cortex, and hippocampus. The left LGN, cerebellum, and frontal cortex retained neuronal components; there was a reduction in the number of dendritic processes on the Purkinje cells of the PKU subject. The loss of neurons in the LGN and occipital cortex is related to the blindness and the neuronal loss in the hippocampus is related to seizure activity.

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