PubMed · 1812048
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J J Sciubba. Evaluating dentigerous cysts.. https://pubmed.ncbi.nlm.nih.gov/1812048/
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OBJECTIVES: The relation between nerve growth factor receptor (NGFR) in the human pre-natal tooth buds and the dental follicle was investigated. In particular, we sought to determine if there is a specific pattern of p75NGFR expression in developing human tooth buds and their surrounding tissue. SETTING AND SAMPLE POPULATION: The Department of Orthodontics at Copenhagen University, Denmark. Histological sections from 11 fetuses, aged 11-21 gestational weeks. METHOD: The sections were studied by conventional immunohistochemistry. RESULTS: Specific spatiotemporal patterns of p75NGFR reactions were observed in the tooth buds and dental follicle: Before matrix production by the ameloblasts, the entire inner enamel epithelium and the entire dental follicle display p75NGFR immunoreactivity; after matrix production is initiated, the immunoreactivity of the matrix producing cells is lost, as is that of the dental follicle adjacent to these matrix-producing cells. CONCLUSION: A unique spatiotemporal distribution of NGFR in the pre-eruptive human tooth bud was demonstrated.
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Pericoronal radiolucencies are common entities of the jaws that account for about 15% to 20% of all biopsy specimens. They are usually slow-growing, benign entities that involve odontogenic epithelium and the crown of a nonerupting tooth. Many lesions develop early in life and are detected during routine radiographic examination. Others are found in later years when a patient presents with a slow-growing swelling. The dentist is often the first provider to encounter these conditions. Thus, he or she must be familiar with their appearance and understand the proper management required.