Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 17224026

Bone formation after sinus augmentation with engineered bone.

Christoph Zizelmann·Ralf Schoen·Marc Christian Metzger·Rainer Schmelzeisen·Alexander Schramm·Britta Dott·Kai-Hendrik Bormann·Nils Claudius Gellrich
View original source ↗Export metadata ↓

Abstract

OBJECTIVES: The aim of the following investigation was to quantify the resorption rate of tissue-engineered bone grafts in the maxillary sinus using volume measurements. MATERIAL AND METHODS: Sinus floor augmentation using autologous bone grafts from the iliac crest (n=17, group 1) was compared with commercially produced transplants of human cells seeded on polyglycolid-polylactid (PLGA) scaffolds (Oral Bone) (n=14, group 2). RESULTS: The total resorption rate for autologous transplants 3 months post operation was 29%, while the tissue-engineered bone showed a resorption rate of 90%. The autologous bone had a bone density of up to 266-551 Hounsfield units (HU), while sufficient mineralization of tissue-engineered bone was found in only one case (152 HU). CONCLUSION: In this clinical study, the use of autologous cancellous bone grafts in sinus augmentation was more reliable than scaffolds containing cultured osteoblasts. Further tissue-engineered bone transplants should be examined to draw general conclusions about the use of tissue-engineered grafts compared with autologous bone grafts for maxillary sinus augmentation.

Explore related subjects

Alveolar Ridge AugmentationBiocompatible MaterialsBone DensityBone ResorptionBone TransplantationDental Implantation, EndosseousDental ImplantsFollow-Up StudiesHumansImage Processing, Computer-AssistedImaging, Three-DimensionalLactic AcidMaxillaMaxillary SinusOsteoblastsOsteogenesisPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerPolymersTissue EngineeringTomography, X-Ray ComputedTransplantation, AutologousComparative StudyJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Christoph Zizelmann, Ralf Schoen, Marc Christian Metzger, Rainer Schmelzeisen, Alexander Schramm, Britta Dott, Kai-Hendrik Bormann, Nils Claudius Gellrich. 2007. Bone formation after sinus augmentation with engineered bone.. https://doi.org/10.1111/j.1600-0501.2006.01295.x

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Influence of the application of platelet-enriched plasma in oral mucosal wound healing.

PURPOSE: The aim of this study was to describe and quantify the therapeutic value of platelet concentrate on the capillary density in oral mucosal wound healing. MATERIAL AND METHODS: The subjects included 10 healthy edentulous patients who underwent bilaterally a sinus floor elevation procedure and a buccal onlay graft with autologous iliac crest bone for maxillary reconstruction. During surgery, platelet-rich plasma (PRP) was prepared from a blood sample taken from the patient. After randomization in a split-mouth design, at one side PRP was administered in the wound and at the contralateral side a placebo. At baseline, microvascular capillary density was scored with the orthogonal polarization spectral (OPS) imaging technique and repeated measurements were performed postoperatively on a daily basis until the tenth day, after which measurements were continued weekly until the fifth postoperative week. RESULTS: Ten patients, five males and five females, were included in the study with a mean age of 54.2+/-9.1 years for females and 57.6+/-6.9 years for males. Donor platelet counts from whole blood had a mean value of 248.5+/-13.5 x 10(9)/l, while the value of platelet counts in the PRP had a mean of 975.9+/-97.9 x 10(9)/l. Wound healing was significantly accelerated in the PRP-treated mucosal wounds during the first 10 postoperative days. After the second week, no obvious differences between the PRP or placebo side could be noted. CONCLUSION: PRP has a strong stimulant effect on capillary regeneration in wound healing. These effects are mainly noticeable during the early stages of wound healing.

Alveolar Ridge Augmentation↗
PubMed2006

Surgical guidelines for dental implant placement.

The goal of an implant supported reconstruction is to obtain optimal aesthetics and function. In order to achieve this, visualisation of the final restorative reconstruction is necessary prior to beginning treatment. The term 'restorative-driven' treatment planning has been used to identify this process. It requires a team approach of specialists, who can develop a multi-disciplinary treatment plan. It starts with an accurate diagnosis, which will lead to a prognosis of each individual tooth and the overall dentition. This information will help the clinician develop the treatment options suitable for tooth replacement. Only when the goals have been defined can the sequence of therapy be established. Working backwards from the wax-up of the final diagnostic model of the proposed treatment assists not only with the management of the complex case, but will help avoid mishaps. Effective communication between the team and the patient is extremely important. Understanding the patient's expectations is key to a successful outcome. Deciding that these expectations are realistic requires a correct diagnosis and an inter-disciplinary treatment plan that is logical. This approach takes time and requires a comprehensive treatment discussion between the team members, and then a thorough case presentation to the patient. Only then will the patient begin to understand the extent of their problem and the options available to reconstruct their mouth.

Alveolar Ridge Augmentation↗