Statistical analysis for haplotype-based matched case-control studies.

H Zhang; G Zheng; Z Li

doi:10.1111/j.1541-0420.2006.00568.x

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Statistical analysis for haplotype-based matched case-control studies.

H Zhang·G Zheng·Z Li

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Abstract

Using unphased genotype data, we studied statistical inference for association between a disease and a haplotype in matched case-control studies. Statistical inference for haplotype data is complicated due to ambiguity of genotype phases. An estimating equation-based method is developed for estimating odds ratios and testing disease-haplotype association. The method potentially can also be applied to testing haplotype-environment interaction. Simulation studies show that the proposed method has good performance. The performance of the method in the presence of departures from Hardy-Weinberg equilibrium is also studied.

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Biometry Case-Control Studies Chromosomes, Human, Pair 22 Gene Frequency Genomics Haplotypes Humans Logistic Models Models, Genetic Polymorphism, Single Nucleotide Sarcoidosis Journal Article Research Support, N.I.H., Extramural

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H Zhang, G Zheng, Z Li. 2006. Statistical analysis for haplotype-based matched case-control studies.. https://doi.org/10.1111/j.1541-0420.2006.00568.x

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