First-trimester screening.

David A Nyberg; Jon Hyett; Jo-Ann Johnson; Vivienne Souter

doi:10.1016/j.rcl.2006.10.017

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PubMed · 17147989

First-trimester screening.

David A Nyberg·Jon Hyett·Jo-Ann Johnson·Vivienne Souter

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Abstract

Screening for fetal chromosome abnormalities, particularly for trisomy 21, has made dramatic advances. Better screening demonstrates that "high-risk" patients--particularly over age 35--can have lower risk of defects than younger unscreened women. This has caused reduction of amniocentesis for older patients and made screening available for younger patients who have the universal 2% to 3% risk. This means lower procedural-related losses of normal fetuses, and better resource allocation. The trend toward first-trimester detection of structural defects continues; a normal survey is reassuring and helps exclude major defects. Based on screening results, patients can be triaged into early follow-up and possible amniocentesis as 14 to 16 weeks, or a later detailed anatomic survey at 18 to 20 weeks.

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Female Fetal Diseases Humans Pregnancy Pregnancy Trimester, First Ultrasonography, Prenatal Journal Article Review

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David A Nyberg, Jon Hyett, Jo-Ann Johnson, Vivienne Souter. 2006. First-trimester screening.. https://doi.org/10.1016/j.rcl.2006.10.017

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