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PubMed · 17026580

A human lymph node in vitro--challenges and progress.

Christoph Giese·Christian D Demmler·Richard Ammer·Stefan Hartmann·Annika Lubitz·Lilja Miller·Riccarda Müller·Uwe Marx
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Abstract

Extracorporeal human lymphatic organs are expected to be excellent tools in the study of human molecular and cellular bases of the immunologic balance and tissue harmony. A rational approach and process to design a device and a procedure to recreate the human lymph node environment in vitro is described with emphasis on T-cell activation. Based on this approach, a bioreactor and a process supporting self-assembly of human lymphatic tissues due to proper emulation of human architecture and homeostasis could be developed.

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BioreactorsCell DifferentiationGelsHumansLymph NodesOrganoidsTissue EngineeringJournal ArticleResearch Support, Non-U.S. Gov't

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Christoph Giese, Christian D Demmler, Richard Ammer, Stefan Hartmann, Annika Lubitz, Lilja Miller, Riccarda Müller, Uwe Marx. 2006. A human lymph node in vitro--challenges and progress.. https://doi.org/10.1111/j.1525-1594.2006.00303.x

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