DNA sequence recognition by bleomycin.

K R Fox

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PubMed · 1690547

DNA sequence recognition by bleomycin.

K R Fox

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Abstract

The ability of bleomycin to cleave DNA fragments containing (TA)n and (GA)n/(CT)n inserts has been investigated. Bleomycin cuts efficiently after AT and GA though not at TA, AG and CT or TC. In the presence of ligands which modify DNA structure new cleavage products appear. It seems that the ability of bleomycin to discriminate between various sequences arises from their structural characteristics rather than merely from base-specific hydrogen bond contacts.

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Base Composition Base Sequence Bleomycin DNA Dactinomycin Drug Interactions Electrophoresis, Polyacrylamide Gel In Vitro Techniques Ligands Plasmids Structure-Activity Relationship Journal Article

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K R Fox. 1990. DNA sequence recognition by bleomycin.. https://pubmed.ncbi.nlm.nih.gov/1690547/

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