Lambda's switch: lessons from a module swap.

Mark Ptashne

doi:10.1016/j.cub.2006.05.037

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Lambda's switch: lessons from a module swap.

Mark Ptashne

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Abstract

A recent experiment has replaced Cro, a crucial component of lambda's genetic switch, with the lac repressor (plus two lac operators). The resulting hybrid phage is viable, but a subtle phenotypic defect explains a puzzle concerning the workings of the switch.

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Bacteriophage lambda DNA-Binding Proteins Evolution, Molecular Gene Expression Regulation, Viral Models, Genetic Operator Regions, Genetic Repressor Proteins Viral Proteins Viral Regulatory and Accessory Proteins Journal Article

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Mark Ptashne. 2006-06-20. Lambda's switch: lessons from a module swap.. https://doi.org/10.1016/j.cub.2006.05.037

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