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PubMed · 16686299

Bicarbonate solutions: update.

Jose A Diaz-Buxo
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Abstract

The use of lactate-based peritoneal dialysis solutions (PDFs) requires hepatic metabolism to convert lactate to bicarbonate. Pure bicarbonate solutions are particularly useful in the setting of hepatic dysfunction and whenever a high risk of lactate accumulation in the blood exists. This article reviews the recent literature related to laboratory findings and clinical experiences with bicarbonate-containing PDFs. The data suggest that bicarbonate-based solutions are safe and well tolerated and that, among patients with severe metabolic acidosis, they provide better correction of that acidosis than do lactate-containing PDFs. In addition, use of bicarbonate solution seems to be associated with improved nutrition, better growth rate in children with end-stage renal disease, better preservation of residual renal function, and, possibly, higher peritoneal ultrafiltration and a lower peritonitis rate. More experience with these solutions and more prospective controlled studies should be encouraged to further characterize the potential benefits of bicarbonate solutions.

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AcidosisBicarbonatesHemodialysis SolutionsHumansLactatesPeritoneal DialysisPeritoneumJournal ArticleReview

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Jose A Diaz-Buxo. 2005. Bicarbonate solutions: update.. https://pubmed.ncbi.nlm.nih.gov/16686299/

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