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PubMed · 16631883

New genes in inflammatory bowel disease: lessons for complex diseases?

Daniel R Gaya·Richard K Russell·Elaine R Nimmo·Jack Satsangi
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Abstract

The chronic inflammatory bowel diseases Crohn's disease and ulcerative colitis are common causes of gastrointestinal disease in northern Europe, affecting as many as one in 250 people. Although mortality is low, morbidity associated with these diseases is substantial. We review the recent advances in the genetics of inflammatory bowel disease, with particular emphasis on the data that have been generated since the discovery of the CARD15 (NOD2) gene in 2001.

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ATP Binding Cassette Transporter, Subfamily B, Member 1AnimalsColitis, UlcerativeCrohn DiseaseEuropeGenetic Predisposition to DiseaseGenetics, PopulationHumansInflammatory Bowel DiseasesPhenotypeToll-Like Receptor 4Journal ArticleResearch Support, Non-U.S. Gov'tReview

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Daniel R Gaya, Richard K Russell, Elaine R Nimmo, Jack Satsangi. 2006-04-15. New genes in inflammatory bowel disease: lessons for complex diseases?. https://doi.org/10.1016/s0140-6736(06)68345-1

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