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PubMed · 16631276

Dynamic nucleosomes and gene transcription.

Jane Mellor
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Abstract

Gene transcription occurs on a nucleosomal template known as chromatin. The recruitment of the transcriptional regulators and the transcription machinery to promoter chromatin is coordinated by a genetic code on the DNA and an epigenetic code on the histone proteins. Chromatin is not a stable environment; rather, the histones, the transcription regulatory proteins and the enzymes that modify and mobilise nucleosomes are in a dynamic state. Thus, at any one time, the factors associated with a region will cooperate or compete to change the rate of inter-conversion between permissive and non-permissive chromatin states, leading to activation or repression of transcription. Here, new concepts such as dynamic nucleosomes and a dynamic histone code in gene transcription are explored.

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AcetylationAmino Acid SequenceAnimalsChromatinDimerizationHistone DeacetylasesHistonesHumansMethylationMolecular Sequence DataNucleosomesTranscription, GeneticJournal ArticleReview

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Jane Mellor. 2006-05-02. Dynamic nucleosomes and gene transcription.. https://doi.org/10.1016/j.tig.2006.03.008

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