Serpin crystal structure and serpin polymer structure.

Ewa Marszal; Andrew Shrake

doi:10.1016/j.abb.2006.03.006

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Serpin crystal structure and serpin polymer structure.

Ewa Marszal·Andrew Shrake

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Abstract

Serpins are a family of structurally homologous proteins having metastable native structures. As a result, a serpin variant destabilized by mutation(s) has a tendency to undergo conformational changes leading to inactive forms, e.g., the latent form and polymer. Serpin polymers are involved in a number of conformational diseases. Although several models for polymer structure have been proposed, the actual structure remains unknown. Here, we provide a comprehensive list of serpins, both free and in complexes, deposited in the Protein Data Bank. Our discussion focuses on structures that potentially can contribute to a better understanding of polymer structure.

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Amino Acid Sequence Models, Molecular Molecular Sequence Data Multiprotein Complexes Mutation Polymers Protein Conformation Serpins Journal Article Review

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Ewa Marszal, Andrew Shrake. 2006-03-23. Serpin crystal structure and serpin polymer structure.. https://doi.org/10.1016/j.abb.2006.03.006

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