Nucleosome dynamics.

Chris Stockdale; Michael Bruno; Helder Ferreira; Elisa Garcia-Wilson; Nicola Wiechens; Maik Engeholm; Andrew Flaus; Tom Owen-Hughes

doi:10.1042/bss0730109

PubMed · 16626292

Nucleosome dynamics.

Chris Stockdale·Michael Bruno·Helder Ferreira·Elisa Garcia-Wilson·Nicola Wiechens·Maik Engeholm·Andrew Flaus·Tom Owen-Hughes

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Abstract

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.

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Adenosine Triphosphate Binding Sites Chromatin Chromatin Assembly and Disassembly DNA Genetic Variation Histones Nucleosomes Protein Processing, Post-Translational Journal Article Research Support, Non-U.S. Gov't Review

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Chris Stockdale, Michael Bruno, Helder Ferreira, Elisa Garcia-Wilson, Nicola Wiechens, Maik Engeholm, Andrew Flaus, Tom Owen-Hughes. 2006. Nucleosome dynamics.. https://doi.org/10.1042/bss0730109

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