The interplay between structure-based design and combinatorial chemistry.

Chamila N Rupasinghe; Mark R Spaller

doi:10.1016/j.cbpa.2006.03.014

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The interplay between structure-based design and combinatorial chemistry.

Chamila N Rupasinghe·Mark R Spaller

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Abstract

The two most lauded drug design approaches from the past century--structure-based design and combinatorial chemistry--are increasingly experiencing integration, whereby the three-dimensional coordinates of a receptor supports the development of combinatorial-based ligand design. A selective polling of the recent literature demonstrates that this can be actualized in many ways.

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Combinatorial Chemistry Techniques Drug Design Molecular Structure Journal Article Review

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Chamila N Rupasinghe, Mark R Spaller. 2006-04-17. The interplay between structure-based design and combinatorial chemistry.. https://doi.org/10.1016/j.cbpa.2006.03.014

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