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PubMed · 16544638

Fast, flexible algorithm for calculating photon correlations.

Ted A Laurence·Samantha Fore·Thomas Huser
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Abstract

We introduce a new algorithm for computing correlations of photon arrival time data acquired in single-molecule fluorescence spectroscopy and fluorescence correlation spectroscopy (FCS). The algorithm is based on rewriting the correlation as a counting operation on photon pairs and can be used with arbitrary bin widths and spacing. The flexibility of the algorithm is demonstrated by use of FCS simulations and single-molecule photon antibunching experiments. Execution speed is comparable to the commonly used multiple-tau correlation technique. Wide bin spacings are possible that allow for real-time software calculation of correlations, even for high count rates.

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AlgorithmsPhotonsRadiation DosageRadiometryReproducibility of ResultsSensitivity and SpecificitySpectrometry, FluorescenceStatistics as TopicEvaluation StudyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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Ted A Laurence, Samantha Fore, Thomas Huser. 2006-03-15. Fast, flexible algorithm for calculating photon correlations.. https://doi.org/10.1364/ol.31.000829

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