Memory efficient folding algorithms for circular RNA secondary structures.

Ivo L Hofacker; Peter F Stadler

doi:10.1093/bioinformatics/btl023

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Memory efficient folding algorithms for circular RNA secondary structures.

Ivo L Hofacker·Peter F Stadler

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Abstract

BACKGROUND: A small class of RNA molecules, in particular the tiny genomes of viroids, are circular. Yet most structure prediction algorithms handle only linear RNAs. The most straightforward approach is to compute circular structures from 'internal' and 'external' substructures separated by a base pair. This is incompatible, however, with the memory-saving approach of the Vienna RNA Package which builds a linear RNA structure from shorter (internal) structures only. RESULT: Here we describe how circular secondary structures can be obtained without additional memory requirements as a kind of 'post-processing' of the linear structures. AVAILABILITY: The circular folding algorithm is implemented in the current version of the of RNAfold program of the Vienna RNA Package, which can be downloaded from http://www.tbi.univie.ac.at/RNA/

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Algorithms Base Sequence Computer Simulation Computing Methodologies Models, Chemical Models, Molecular Molecular Sequence Data Nucleic Acid Conformation RNA Sequence Analysis, RNA Software Journal Article Research Support, Non-U.S. Gov't

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Ivo L Hofacker, Peter F Stadler. 2006-02-01. Memory efficient folding algorithms for circular RNA secondary structures.. https://doi.org/10.1093/bioinformatics%2Fbtl023

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