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PubMed · 1638116

Myc and Max function as a nucleoprotein complex.

E M Blackwood·L Kretzner·R N Eisenman
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Abstract

The Myc family of oncoproteins are thought to regulate proliferation and differentiation in a wide variety of cell types. Recent studies show that Myc proteins form sequence-specific DNA-binding complexes with Max, a new member of the helix-loop-helix leucine zipper protein class. The properties of the Myc-Max complex suggest a mechanism for Myc's function in both normal and neoplastic cell behavior.

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Basic-Leucine Zipper Transcription FactorsDNA-Binding ProteinsGene Expression RegulationNucleoproteinsProto-Oncogene Proteins c-mycTranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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E M Blackwood, L Kretzner, R N Eisenman. 1992. Myc and Max function as a nucleoprotein complex.. https://doi.org/10.1016/s0959-437x(05)80278-3

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