PubMed · 1636960
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
E Herrera Justiniano. 1992. [Neurosecretory dysfunction].. https://pubmed.ncbi.nlm.nih.gov/1636960/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Catabolic patients are resistant to the actions of GH. This resistance is probably multifactorial in origin. It is likely that both the fasting state and circulating factors, possibly cytokines, are aetiological. Resistance or insensitivity is characterized by raised GH levels, low IGF-I levels and a reduced anabolic response to GH.
Explore the source record for details and available documents.
The cornerstones in the evaluation of short stature are auxology and biochemical testing. Traditionally, the diagnosis of growth hormone (GH) deficiency has been based upon measurement of serum concentrations of GH following either physiological or pharmacological stimulation, or determination of spontaneous GH secretory patterns. Assessment of pituitary GH secretion is, however, fraught with problems, including the nonphysiological nature of provocative testing, the reliance on arbitrary definitions of subnormal responses, the inadequate attention paid to age- and puberty-related variability, and the dependence upon assays with marginal concordancy. It is proposed that the evaluation of short stature is best pursued by careful auxology plus assessment of the insulin-like growth factor (IGF) axis, with particular attention to measurements of serum concentrations of IGF-I and IGF-binding protein-3. The diagnosis of IGF deficiency can then be readily established, and its etiology pursued logically.