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PubMed · 16351081

Self-assembling a molecular pegboard.

Kyle Lund·Yan Liu·Stuart Lindsay·Hao Yan
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Abstract

This paper describes the design, construction, and application of a self-assembled, chemically addressable DNA nanogrid composed of DNA tiles of nanometer dimensions. This self-assembled structure permits precise placement of molecules at predetermined locations on a "molecular pegboard". We used the indexed DNA nanogrids to identify single molecules of DNA that hybridize at particular locations.

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DNAMicroarray AnalysisMicroscopy, Atomic ForceModels, MolecularNanostructuresNucleic Acid ConformationNucleic Acid HybridizationStreptavidinJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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Kyle Lund, Yan Liu, Stuart Lindsay, Hao Yan. 2005-12-21. Self-assembling a molecular pegboard.. https://doi.org/10.1021/ja0568446

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